How does Semaglutide work for weight loss?

Semaglutide is the latest addition to the arsenal of medications that promote weight loss. Sold under the brand name Ozempic, this drug was first introduced to treat diabetes mellitus, however, later it was discovered that it can promote weight loss as well. As such focus has shifted on using it as a weight loss product. In this article we will learn how does semaglutide works for weight loss, has it been licensed for using it as a weight loss product, how many numbers it can help you to drop in the scale, and other such questions.

How does Semaglutide work for weight loss – the mechanism of action

Humans have a hormone called Glucagon-Like Peptide-1 (GLP-1). It is produced by some intestinal cells in response to blood sugar that increases after a meal. GLP-1 binds to its receptors in the β-cells of the pancreas. This causes the β-cells of the pancreas to release insulin to promote utilization of the sugar in the blood by cells of the body. Semaglutide is a synthetic molecule that has a similar structure as GLP-1. As such it acts as a GLP-1 receptor agonist. It can similarly bind with β-cells and cause similar action resulting in the release of insulin. Selmagltuide suppresses appetite, thereby decreasing food intake and also slows down digestion in the stomach. In this way, it can reduce body weight as well.

Is Semagltuide licensed for weight loss?

Yes, in June 2021 the FDA (United States Food and Drugs Administration), Semaglutide received approval for once-weekly use to treat obesity and to promote weight loss.

How much weight one can lose with Semaglutide?

A study published in the New England Journal of Medicine reported that once-weekly semaglutide use resulted in an average weight loss of 15.3kg or 33.7 lbs over 68 weeks. This study included 1961 participants with a BMI of more than 30.

Semaglutide Side Effects

Semaglutide was found to be quite safe when it came to the safety profile, however, few people felt nauseous with its use, and a minority developed gall bladder stone (cholelithiasis) as well. In the study, none developed fatal side effects.

Can non-diabetic use semaglutide?

Yes, non-diabetics can use semaglutide. The study I have mentioned above was conducted on non-diabetic obese people.

Conclusion

As of now, Semaglutide is the latest drug approved for weight loss by the FDA, at a weekly dose of 2.4mg. However, it is to be remembered, that it should be used as an adjunct or supplementary to exercise and diet control. And it should be taken only under a doctor’s prescription.